Oldani A, Ferini-Strambi L, Zucconi M, Stankov B, Fraschini F, Smirne S
Sleep Disorders Centre, IRCCS H San Raffaele, Milan, Italy.
Neuroreport. 1994 Dec 30;6(1):132-4. doi: 10.1097/00001756-199412300-00034.
The present study objectively evaluated the efficacy of oral 5 mg day-1 melatonin in advancing the sleep-wake rhythm in patients with delayed sleep phase syndrome (DSPS). Six patients underwent ambulatory sleep monitoring for 72 h before and 48 h after 1 month of melatonin treatment. In each patient melatonin was administered on the basis of his own estimated dim light melatonin onset (DLMO) delay. Mean advances in sleep onset time of 115 min and in final awakening hour of 106 min were found after treatment, with no significant changes in sleep architecture parameters. Our study objectively confirms previous data obtained by a sleep-wake subjective diary on the efficacy of melatonin DSPS.
本研究客观评估了每日口服5毫克褪黑素对延迟睡眠相位综合征（DSPS）患者睡眠-觉醒节律提前的疗效。6例患者在褪黑素治疗1个月前后分别接受了72小时的动态睡眠监测，治疗前监测72小时，治疗后监测48小时。每位患者均根据自身估算的暗光褪黑素起始时间（DLMO）延迟来服用褪黑素。治疗后发现睡眠起始时间平均提前115分钟，最终觉醒时间平均提前106分钟，睡眠结构参数无显著变化。我们的研究客观证实了之前通过睡眠-觉醒主观日记获得的关于褪黑素治疗DSPS疗效的数据。
