Umemoto S, Kawai Y, Senba E
Department of Anatomy and Neurobiology Wakayama Medical College, Japan.
Neuroreport. 1994 Dec 30;6(1):201-4. doi: 10.1097/00001756-199412300-00051.
Various kinds of stressors induce immediate early genes (IEGs) in discrete brain regions. We recently reported the reduced response of Fos expression in the hypothalamic paraventricular nucleus (PVH) when rats are repeatedly exposed to immobilization (IMO) stress. In this study, using in situ hybridization histochemistry, we further extended the research to other IEGs, and the results showed that prior exposure to IMO for 6 days suppressed the induction of fosB, junB and NGFI-B, but NGFI-A, mRNAs in response to a challenge IMO on day 7, suggesting that repeated stress has different effects on the transcription of NGFI-A and the other IEGs, in the PVH.
各种应激源可在离散的脑区诱导即刻早期基因（IEGs）。我们最近报道，当大鼠反复暴露于束缚（IMO）应激时，下丘脑室旁核（PVH）中Fos表达的反应减弱。在本研究中，我们使用原位杂交组织化学方法，将研究进一步扩展到其他IEGs，结果表明，预先暴露于IMO 6天可抑制fosB、junB和NGFI-B的诱导，但对第7天再次暴露于IMO刺激时NGFI-A的mRNA诱导无抑制作用，提示反复应激对PVH中NGFI-A和其他IEGs的转录有不同影响。
