Bortolotti M, Coccia G, Brunelli F, Sarti P, Mazza M, Bagnato F, Barbara L
Divisione di Gastroenterologia, Ospedale Galliera, Genova, Italy.
Ital J Gastroenterol. 1994 Oct-Nov;26(8):379-82.
Oesophageal motor activity was recorded manometrically with a low compliance system in 16 patients with achalasia and a slightly dilated oesophagus. After a basal recording period, nifedipine 20 mg was given sublingually to 9 patients and isosorbide dinitrate 5 mg to another 7 patients. Lower oesophageal sphincter pressure (LESp) and oesophageal body pressure wave amplitude were measured for 60 min after drug administration. Both drugs decreased LESp and pressure wave amplitude, but the effect of isosorbide dinitrate was faster and more intense than that of nifedipine. There was a lower inhibitory effect of nifedipine on the amplitude of pressure waves than on LESp, while isosorbide dinitrate inhibited with a similar intensity both LESp and pressure waves.
使用低顺应性系统通过测压法记录了16例贲门失弛缓症且食管轻度扩张患者的食管运动活动。在基础记录期后，9例患者舌下含服20毫克硝苯地平，另外7例患者舌下含服5毫克硝酸异山梨酯。给药后60分钟测量食管下括约肌压力（LESp）和食管体压力波幅度。两种药物均降低了LESp和压力波幅度，但硝酸异山梨酯的作用比硝苯地平更快、更强。硝苯地平对压力波幅度的抑制作用低于对LESp的抑制作用，而硝酸异山梨酯对LESp和压力波的抑制强度相似。
