Claes L E, Ludwig J, Margevicius K J, Dürselen L
Abteilung für Unfallchirurgische Forschung und Biomechanik, Universität Ulm, Germany.
J Appl Biomater. 1995 Spring;6(1):35-41. doi: 10.1002/jab.770060106.
In ligament replacement cases where the artificial ligament has worn and partially or totally ruptured, the released wear particles have been associated with a chronic synovitis that inhibits integration of the ligament and contributes to the ultimate failure of the device. In this study, the biological response to ligament wear particles from nine different artificial ligaments was quantitatively evaluated in vivo. Wear particles, the majority of which were < 7 microns, were generated in vitro. These particles were injected into rabbit knee joints, and the biological response as well as the systemic migration of the particles were evaluated histologically after 4 weeks. The extent of the inflammatory reaction to the ligament wear particles was found to be significantly (p < 0.05) influenced by the type of material implanted. No particles were found in the regional lymph nodes or in the spleen, liver, kidney, or lung.
在人工韧带磨损且部分或完全断裂的韧带置换病例中，释放出的磨损颗粒与慢性滑膜炎有关，这种滑膜炎会抑制韧带的整合，并导致该装置最终失效。在本研究中，对九种不同人工韧带的磨损颗粒的生物学反应进行了体内定量评估。磨损颗粒在体外产生，其中大部分小于7微米。将这些颗粒注入兔膝关节，4周后通过组织学评估生物学反应以及颗粒的全身迁移情况。发现对韧带磨损颗粒的炎症反应程度受植入材料类型的显著影响（p < 0.05）。在区域淋巴结或脾脏、肝脏、肾脏或肺中未发现颗粒。
