Kindt-Larsen T, Smith D B, Jensen J S
Wolff & Kaaber A/S, Farum, Denmark.
J Appl Biomater. 1995 Spring;6(1):75-83. doi: 10.1002/jab.770060111.
A new bone cement was developed with the purpose of reducing the adverse biological effects during cementation of implants. This bone cement is characterized by lower exotherm, low release of monomer, low residual content of monomer, and retained physical properties. The essential innovation was substitution of half of the methylmethacrylate (MMA) in the monomer with long chain, high molecular weight, less volatile, and less soluble methacrylates (n-decylmethacrylate, isobornyl-methacrylate), as well as alteration of the accelerator system to a mix of dihydroxypropyl-p-toluidine and N,N-dimethyl-p-toluidine. The powder contains butylmethacrylate-MMA copolymers. These measures lower the glass-transition temperature, and permit more complete mixing in an integrated package, mixing, and delivery system consisting of a vacuum packed, double chamber pouch. The porosity was reduced to about 2% and the largest voids measured 0.1 mm. The polymerization exotherm was reduced to 58 degrees C. The compressive strength was 82 MPa, the four-point bending strength 55 MPa, the flexural modulus 2.24 GPa, the tensile strength 32 MPa, and the shear strength 36 MPa. The fracture toughness was 0.89 MPa square root of cm. These mechanical properties together with the fatigue life were on level with manually mixed, conventional PMMA bone cements.
研发了一种新型骨水泥，旨在减少植入物骨水泥固定过程中的不良生物学效应。这种骨水泥的特点是放热较低、单体释放量低、单体残留量低且物理性能得以保留。其关键创新在于，用长链、高分子量、挥发性较低且溶解性较小的甲基丙烯酸酯（甲基丙烯酸正癸酯、异冰片基甲基丙烯酸酯）替代了单体中一半的甲基丙烯酸甲酯（MMA），并将促进剂体系改为二羟丙基对甲苯胺和N，N - 二甲基对甲苯胺的混合物。粉末包含甲基丙烯酸丁酯 - MMA共聚物。这些措施降低了玻璃化转变温度，并允许在由真空包装的双腔袋组成的一体化包装、混合和输送系统中实现更完全的混合。孔隙率降低至约2%，最大孔隙尺寸为0.1毫米。聚合放热降低至58摄氏度。抗压强度为82兆帕，四点弯曲强度为55兆帕，弯曲模量为2.24吉帕，拉伸强度为32兆帕，剪切强度为36兆帕。断裂韧性为0.89兆帕根号厘米。这些力学性能以及疲劳寿命与手动混合的传统PMMA骨水泥相当。
