Perdereau B, Campana F, Vilcoq J R, de la Rochefordière A, Barbaroux C, Fourquet A, Magdelenat H
Laboratoire de radiopathologie clinique, institut Curie, Paris, France.
Bull Cancer. 1994 Aug;81(8):659-69.
The aim of the paper consists to select criterias of the therapeutic effect of superoxide-dismutase (PEG-SOD) administrated as an ointment twice a day for 3 months. An original scoring method including qualitative and quantitative data was set up in order to appreciate the importance of the fibrosis and its variations when under local administration of PEG-SOD. Clinical and paraclinical controls were made as T0, T1 (6 weeks), T2 (3 months), T3 (6 months). After 6 months, results enabled us to show PEG-SOD in its galenic form was efficient on radiofibrosis with a 41% score reduction compared to pretreatment score T0, thus an improvement of nearly half of the potential theoretical recovery. The therapeutic efficiency was greater on the most recent fibrosis and there was a chronological order to the different recovery stages. After 6 weeks of administration pains were reduced or stopped; then after 3 months of treatment fibrous texture broke up and softened. An effective reduction of the surface as well as lightened of the pigmentation would not usually start until the 4th month after the start of treatment. PEG-SOD is thus an enzyme the therapeutic interest of which offers interesting prospects. The score which was set up enable a fair evaluation of the intensity and the variations of the treated fibrosis. A prospective study is currently on going in order to research the biological conditions in which the enzyme reacts.
本文的目的是选择超氧化物歧化酶（聚乙二醇化超氧化物歧化酶，PEG-SOD）作为软膏剂每天给药两次，持续3个月的治疗效果标准。建立了一种包括定性和定量数据的原始评分方法，以评估在局部应用PEG-SOD时纤维化的重要性及其变化。在T0、T1（6周）、T2（3个月）、T3（6个月）进行临床和副临床对照。6个月后，结果表明，与治疗前T0评分相比，聚乙二醇化超氧化物歧化酶的药剂形式对放射性纤维化有效，评分降低了41%，因此几乎实现了潜在理论恢复的一半改善。对最新的纤维化治疗效果更佳，且不同恢复阶段存在时间顺序。给药6周后疼痛减轻或停止；然后在治疗3个月后纤维质地分解并软化。通常直到治疗开始后第4个月才会出现有效减少面积以及色素沉着减轻的情况。因此，聚乙二醇化超氧化物歧化酶是一种具有治疗意义且前景可观的酶。所建立的评分能够对治疗的纤维化的强度和变化进行合理评估。目前正在进行一项前瞻性研究，以探究该酶发生反应的生物学条件。
