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[超氧化物歧化酶治疗2例放射性硬化症]

[Superoxide dismutase treatment of 2 cases of radiation-induced sclerosis].

作者信息

Emerit J, Michelson A M, Robert H G, Chomette G, Guérin R A, Blondon J, Bertrand M

出版信息

Sem Hop. 1983 Jan 27;59(4):277-81.

PMID:6301059
Abstract

Two patients with severe radio-induced necrosis were treated with bovine copper superoxide dismutase encapsulated in lysosomes (SOD). Two milligrams were injected subcutaneously every other day. This therapy was apparently effective on radio-induced inflammation and fibrosis. These are preliminary results that need confirmation. They suggest that SOD is useful, not only before radiation exposure, as a preventive, but also after exposure, as curative treatment for radiation injury.

摘要

两名患有严重放射性坏死的患者接受了包裹在溶酶体中的牛铜超氧化物歧化酶(SOD)治疗。每隔一天皮下注射2毫克。这种疗法对放射性炎症和纤维化显然有效。这些是需要确认的初步结果。它们表明,SOD不仅在辐射暴露前作为预防措施有用,而且在暴露后作为辐射损伤的治疗方法也有用。

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[Superoxide dismutase treatment of 2 cases of radiation-induced sclerosis].[超氧化物歧化酶治疗2例放射性硬化症]
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[Action of liposomal superoxide dismutase on measurable radiation-induced fibrosis].[脂质体超氧化物歧化酶对可测量的辐射诱导纤维化的作用]
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[Superoxide dismutase (Cu/Zn) in cutaneous application in the treatment of radiation-induced fibrosis].[超氧化物歧化酶(铜/锌)在皮肤应用中治疗放射性纤维化的研究]
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Treatment of radiofibrosis with liposomal superoxide dismutase. Preliminary results of 50 cases.脂质体超氧化物歧化酶治疗放射性纤维化:50例初步结果
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Topical application of superoxide dismutase cream.超氧化物歧化酶乳膏的局部应用。
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Long-term hearing loss in gerbils with bacterial meningitis treated with superoxide dismutase.用超氧化物歧化酶治疗的细菌性脑膜炎沙鼠的长期听力损失。
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Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats.从汉逊德巴利酵母中获得的超氧化物歧化酶对大鼠II型胶原诱导性关节炎的抗炎活性。
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Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.辐射诱导的纤维化:机制与缓解机会。美国国立癌症研究所研讨会报告,2016年9月19日
Radiat Res. 2017 Jul;188(1):1-20. doi: 10.1667/RR14784.1. Epub 2017 May 10.
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The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD.锰超氧化物歧化酶作为人类疾病生物标志物的功能作用以及一种新型人类重组锰超氧化物歧化酶亚型的治疗潜力。
Biomed Res Int. 2014;2014:476789. doi: 10.1155/2014/476789. Epub 2014 Jan 6.