Rucker R B, Stites T
Department of Nutrition, University of California, Davis.
Nutrition. 1994 Nov-Dec;10(6):507-13.
Newer aspects of vitamin function are reviewed from a biochemical perspective. Specifically, six themes are developed that include 1) mechanisms and biochemical functions important to oxidant defense, 2) new functions associated with the actions of vitamin D, 3) vitamin K and calcium homeostasis, 4) folic acid and the methylation of DNA, 5) beta-carotene and cellular communication, and 6) newly identified roles for vitamin B6. A decade ago, it was considered highly speculative to propose approaches to disease prevention that involved vitamin supplementation. Nutrition paradigms important to vitamin function, however, have now shifted to include more focus on disease prevention and consideration of supplements. Considerable work has also evolved to provide basic biochemical and physiological mechanisms as bases for the interaction between vitamin status and health.
从生化角度对维生素功能的新进展进行了综述。具体而言，阐述了六个主题，包括1）对氧化防御重要的机制和生化功能，2）与维生素D作用相关的新功能，3）维生素K与钙稳态，4）叶酸与DNA甲基化，5）β-胡萝卜素与细胞通讯，以及6）维生素B6新确定的作用。十年前，提出通过补充维生素来预防疾病的方法被认为极具推测性。然而，如今对维生素功能重要的营养模式已发生转变，更加注重疾病预防和对补充剂的考虑。也开展了大量工作来提供基本的生化和生理机制，作为维生素状态与健康之间相互作用的基础。
