Guirao X, Franch G, Gil M J, García-Domingo M I, Girvent M, Sitges-Serra A
Department of Surgery, Hospital Universitari del Mar, Barcelona, Spain.
Nutrition. 1994 Nov-Dec;10(6):558-61.
ECW, and particularly its interstitial component, expands easily with malnutrition, sepsis, and trauma and after aggressive intravenous fluid therapy. In this scenario, hypoalbuminemia is usually the result of both an increased capillary escape rate due to leaky endothelium and increased distribution volume; this can be worsened by artificial intravenous nutrition with sodium, water, and glucose. Monitoring ECW is essential during TPN. Short-term changes in weight and serum albumin concentration are helpful to control ECW volume and prevent ECW expansion. Tetrapolar bioimpedance analysis is a promising technique for accurate bedside measurement of changes in body fluid compartments.
细胞外液（ECW），尤其是其细胞间质成分，在营养不良、脓毒症、创伤以及积极的静脉补液治疗后容易扩张。在这种情况下，低白蛋白血症通常是由于内皮细胞渗漏导致毛细血管逃逸率增加和分布容积增加共同作用的结果；人工静脉输注钠、水和葡萄糖营养时，这种情况可能会恶化。在全胃肠外营养（TPN）期间监测细胞外液至关重要。体重和血清白蛋白浓度的短期变化有助于控制细胞外液量并防止其扩张。四极生物电阻抗分析是一种很有前景的技术，可用于准确床边测量体液 compartments 的变化。
