Liu B H, Dai E L, Cao T M
Dept. of TCM, Second Affiliated Hospital, Lanzhou Medical College.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Nov;14(11):658-60.
The efficacy of TCM-WM therapy in treating adult primary nephrotic syndrome in comparing with using Western medicine alone and its influence on patient's hemorheology was investigated. The results showed that with the therapy of combined therapy the clinical remission rate and total effective rate were 65.4% and 88.5%, while that of Western medicine alone were 37.0% and 59.3% respectively. There was significant difference between the above-mentioned two groups (P < 0.01). Adverse effect scores with combined therapy were much lower than that of WM alone (P < 0.01). The recurrence rate of the illness with TCM-WM and WM therapy were 7.25% and 53.13% respectively (P < 0.01). Furthermore, the combined treatment of TCM-WM could remarkably improve the blood viscosity and reduce the content of fibrinogen. It was suggested that Syndrome Differentiation with the administration of steroid could not only ameliorate the adverse effects of steroid but promote the efficacy and reduce the recurrence of the disease. Besides, the addition of blood-activating and stasis-removing herbs could also improve the blood viscosity and the impaired fibrinolysis.
研究了中西医结合疗法治疗成人原发性肾病综合征的疗效，并与单纯使用西药进行比较，以及其对患者血液流变学的影响。结果显示，中西医结合疗法的临床缓解率和总有效率分别为65.4%和88.5%，而单纯西药治疗的临床缓解率和总有效率分别为37.0%和59.3%。上述两组之间存在显著差异（P<0.01）。中西医结合疗法的不良反应评分远低于单纯西药治疗（P<0.01）。中西医结合疗法和西药疗法的疾病复发率分别为7.25%和53.13%（P<0.01）。此外，中西医结合治疗可显著改善血液粘度，降低纤维蛋白原含量。提示辨证使用激素不仅可改善激素的不良反应，还可提高疗效，降低疾病复发率。此外，加用活血化瘀中药还可改善血液粘度和纤溶功能障碍。
