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一段携带氨苄青霉素抗性基因的脱氧核糖核酸片段在大肠杆菌复制子之间的易位。

Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Eschericha coli.

作者信息

Bennett P M, Richmond M H

出版信息

J Bacteriol. 1976 Apr;126(1):1-6. doi: 10.1128/jb.126.1.1-6.1976.

DOI:10.1128/jb.126.1.1-6.1976
PMID:770415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC233252/
Abstract

A number of well-characterized R plasmids (R1drd 19. K1.R100-1, R46, R55-1, R64-11, R388, and R751) will mobilize an integrated amp gene from the chromosome of Escherichia coli K-12. R391 will not act in this way. The process involves recombination, and in each case the mobilizing plasmid acquires an additional piece of deoxyribonucleic acid of molecular weight 4 X 10(6). Acquisition of this deoxyribonucleic acid may impair the transfer properties of the recombinant plasmid in some cases. The process will occur in a recA background.

摘要

一些特征明确的R质粒（R1drd 19、K1、R100 - 1、R46、R55 - 1、R64 - 11、R388和R751）能够从大肠杆菌K - 12的染色体上动员整合的氨苄青霉素基因。R391则不会以这种方式起作用。该过程涉及重组，并且在每种情况下，动员质粒都会获得一条分子量为4×10⁶的额外脱氧核糖核酸片段。在某些情况下，获得这种脱氧核糖核酸可能会损害重组质粒的转移特性。该过程将在recA背景下发生。

相似文献

1
Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Eschericha coli.一段携带氨苄青霉素抗性基因的脱氧核糖核酸片段在大肠杆菌复制子之间的易位。
J Bacteriol. 1976 Apr;126(1):1-6. doi: 10.1128/jb.126.1.1-6.1976.
2
Recombinant plasmids formed in vivo carrying and expressing two incompatibility regions.在体内形成的携带并表达两个不相容区域的重组质粒。
J Gen Microbiol. 1979 Oct;114(2):467-70. doi: 10.1099/00221287-114-2-467.
3
Properties of the relaxation complexes of supercoiled deoxyribonucleic acid and protein of the R plasmids R64, R28K, and R6K.R质粒R64、R28K和R6K的超螺旋脱氧核糖核酸与蛋白质的松弛复合物的性质
J Bacteriol. 1974 Oct;120(1):545-8. doi: 10.1128/jb.120.1.545-548.1974.
4
Translocation of an ampicillin resistance determinant within an R-factor aggregate in Salmonella panama.巴拿马沙门氏菌中R因子聚集体内氨苄青霉素抗性决定子的易位
Antonie Van Leeuwenhoek. 1978;44(2):203-18. doi: 10.1007/BF00643223.
5
[Incorporation of the ampicillin resistance transposon into the Escherichia coli K-12 chromosome and into plasmids].[将氨苄青霉素抗性转座子整合到大肠杆菌K-12染色体及质粒中]
Genetika. 1979;15(2):209-19.
6
Class of small multicopy plasmids originating from the mutant antibiotic resistance factor R1 drd-19B2.源自突变抗生素抗性因子R1 drd - 19B2的小型多拷贝质粒类别。
J Bacteriol. 1975 Aug;123(2):658-65. doi: 10.1128/jb.123.2.658-665.1975.
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Transposition of a deoxyribonucleic acid sequence encoding trimethoprim and streptomycin resistances from R483 to other replicons.编码甲氧苄啶和链霉素抗性的脱氧核糖核酸序列从R483转位至其他复制子。
J Bacteriol. 1976 Mar;125(3):800-10. doi: 10.1128/jb.125.3.800-810.1976.
8
Isolation, by tetracycline selection, of small plasmids derived from R-factor R12 in Escherichia coli K-12.通过四环素筛选，从大肠杆菌K-12中的R因子R12分离出小质粒。
J Bacteriol. 1976 Jul;127(1):644-55. doi: 10.1128/jb.127.1.644-655.1976.
9
Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: identity of laboratory-constructed plasmids and clinical isolates.介导氨苄西林耐药性的质粒脱氧核糖核酸序列的转座：实验室构建质粒与临床分离株的一致性
J Bacteriol. 1977 Jan;129(1):530-3. doi: 10.1128/jb.129.1.530-533.1977.
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Molecular nature of two beta-lactamase-specifying plasmids isolated from Haemophilus influenzae type b.从b型流感嗜血杆菌中分离出的两种β-内酰胺酶编码质粒的分子特性
J Bacteriol. 1976 Apr;126(1):439-46. doi: 10.1128/jb.126.1.439-446.1976.

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J Bacteriol. 1981 Feb;145(2):713-21. doi: 10.1128/jb.145.2.713-721.1981.
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Antimicrob Agents Chemother. 1980 Nov;18(5):667-74. doi: 10.1128/AAC.18.5.667.
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New translocation sequence mediating tetracycline resistance found in Escherichia coli pathogenic for piglets.在仔猪致病性大肠杆菌中发现介导四环素抗性的新易位序列。
Antimicrob Agents Chemother. 1980 Jul;18(1):200-5. doi: 10.1128/AAC.18.1.200.
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本文引用的文献

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Simplified quantitative electron microscopy of biopolymers.生物聚合物的简化定量电子显微镜技术
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Penicillinase synthesis controlled by infectious R factors in Enterobacteriaceae.肠杆菌科中由传染性R因子控制的青霉素酶合成
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Properties of an R factor from Pseudomonas aeruginosa.铜绿假单胞菌R因子的特性
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Beginning a genetic analysis of conjugational transfer determined by the F factor in Escherichia coli by isolation and characterization of transfer-deficient mutants.通过分离和鉴定转移缺陷型突变体，对大肠杆菌中由F因子决定的接合转移进行遗传分析。
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A transmissible resistance element from a strain of Pseudomonas aeruginosa containing no detectable extrachromosomal DNA.来自一株铜绿假单胞菌的可传递抗性元件，该菌株不含可检测到的染色体外DNA。
J Gen Microbiol. 1972 Sep;72(2):269-79. doi: 10.1099/00221287-72-2-269.
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Transposition of ampicillin resistance from RP4 to other replicons.氨苄青霉素抗性从RP4转座至其他复制子。
Mol Gen Genet. 1974;132(1):31-40. doi: 10.1007/BF00268228.
9
Trimethoprim R factors in enterobacteria from clinical specimens.临床标本中肠杆菌科细菌的甲氧苄啶R因子
J Med Microbiol. 1974 May;7(2):169-77. doi: 10.1099/00222615-7-2-169.
10
The chromosomal integration of a -lactamase gene derived from the P-type R-factor RP1 in Escherichia coli.源自P型R因子RP1的β-内酰胺酶基因在大肠杆菌中的染色体整合。
Genet Res. 1972 Oct;20(2):231-7. doi: 10.1017/s0016672300013732.