Hall M G, Ferrell W R, Sturrock R D, Hamblen D L, Baxendale R H
Institute of Physiology, University of Glasgow.
Br J Rheumatol. 1995 Feb;34(2):121-5. doi: 10.1093/rheumatology/34.2.121.
Proprioceptive sensory feedback is utilized by the central nervous system for conscious appreciation of the position and movement of the body and limbs. In patients with the hypermobility syndrome (HMS), it has been suggested that there is alteration of proprioceptive acuity. Proprioceptive performance of the knee joint was investigated in 10 female subjects who suffered from HMS using a threshold detection paradigm (accurate determination of the onset and direction of knee joint displacement at constant angular velocity). Compared to age- and sex-matched controls, HMS subjects showed significantly higher detection levels at starting knee flexion angles of 30 degrees P < 0.001) and 5 degrees (P < 0.001). Control subjects showed no significant difference in threshold acuity between the sexes (at 5 degrees P = 0.63, at 30 degrees P = 0.48). The increased acuity in proprioception observed towards full extension in the control population (P < 0.001) was absent in the HMS subjects (P = 0.596). Findings reported here suggest that HMS subjects have poorer proprioceptive feedback than controls. Reduced sensory feedback may lead to biomechanically unsound limb positions being adopted. Such a mechanism may allow acceleration of degenerative joint conditions, and may account for the increased prevalence of such conditions seen with HMS subjects.
本体感觉反馈被中枢神经系统用于对身体和四肢的位置及运动进行有意识的感知。在患有活动过度综合征（HMS）的患者中，有人提出本体感觉敏锐度存在改变。使用阈值检测范式（精确确定膝关节在恒定角速度下位移的起始和方向）对10名患有HMS的女性受试者的膝关节本体感觉表现进行了研究。与年龄和性别匹配的对照组相比，HMS受试者在起始膝关节屈曲角度为30度（P < 0.001）和5度（P < 0.001）时显示出明显更高的检测水平。对照组受试者在性别之间的阈值敏锐度上没有显著差异（5度时P = 0.63，30度时P = 0.48）。在对照组人群中观察到的向完全伸展方向本体感觉敏锐度增加（P < 0.001）在HMS受试者中并不存在（P = 0.596）。此处报告的研究结果表明，HMS受试者的本体感觉反馈比对照组差。感觉反馈减少可能导致肢体采取生物力学上不合理的姿势。这样一种机制可能会加速关节退行性病变的发展，并且可能解释了在HMS受试者中此类病症患病率增加的原因。
