Agarwal P
Coutant Institute of Mathematical Sciences, New York University, NY 10012, USA.
Comput Appl Biosci. 1994 Dec;10(6):647-55. doi: 10.1093/bioinformatics/10.6.647.
In developmental biology, modeling and simulation play an important role in understanding cellular interactions. We suggest a simple language, the Cell Programming Language (CPL), to write computer programs to describe this behavior. Using these programs, it is possible to simulate and visualize intercellular behavior. We employ CPL to model aggregation in Dictyostelium in response to a chemotactic agent. CPL programs are utilized to model a variety of aggregation behavior including streaming, spiral formation and the effect of amoeba density on aggregation patterns. We believe CPL is a useful tool for developing, understanding and checking biological models that utilize cellular interactions.
在发育生物学中，建模与模拟对于理解细胞间相互作用起着重要作用。我们提出一种简单的语言——细胞编程语言（CPL），用于编写计算机程序来描述这种行为。利用这些程序，可以模拟并可视化细胞间行为。我们使用CPL对盘基网柄菌在趋化剂作用下的聚集进行建模。CPL程序被用于对包括流动、螺旋形成以及变形虫密度对聚集模式的影响等多种聚集行为进行建模。我们相信CPL是开发、理解和检验利用细胞间相互作用的生物学模型的有用工具。
