Agarwal P
Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York 10012, USA.
J Theor Biol. 1995 Sep 7;176(1):79-89. doi: 10.1006/jtbi.1995.0178.
In developmental biology, modeling and simulation play an important role in understanding cellular interactions. In this paper a simple language, the Cell Programming Language (CPL), is suggested for writing programs that describe this behavior. Using these programs, it is possible to simulate and visualize intercellular behavior. CPL is used to model cellular segregation based upon the differential adhesion hypothesis. Results indicate that a high degree of segregation can be produced in a mixture of cells by allowing random motion. The engulfment of a tissue by a less adhesive tissue is also observed when the two tissues are placed in contact. Both these simulations utilize only local interactions and random motion of cells. Earlier simulations used long-range interactions to observe similar effects. The present simulations prove that random motion of cells can produce long-range effects.
在发育生物学中，建模与模拟在理解细胞间相互作用方面发挥着重要作用。本文提出了一种简单的语言——细胞编程语言（CPL），用于编写描述这种行为的程序。利用这些程序，可以模拟和可视化细胞间行为。CPL用于基于差异黏附假说对细胞分离进行建模。结果表明，通过允许随机运动，在细胞混合物中可产生高度的分离。当将两种组织放置在一起接触时，还观察到黏附性较低的组织对另一种组织的吞噬现象。这两种模拟均仅利用细胞的局部相互作用和随机运动。早期的模拟使用长程相互作用来观察类似的效果。目前的模拟证明，细胞的随机运动可产生长程效应。
