Sutherland W H, Walker R J, Lewis-Barned N J, Pratt H, Tillman H C
Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
Clin Chim Acta. 1994 Nov;231(1):29-38. doi: 10.1016/0009-8981(94)90251-8.
Plasma newly synthesised cholesteryl ester transfer (NCET) rates from high density lipoproteins (HDL) to very low density lipoproteins (VLDL) and low density lipoproteins lipoproteins (LDL) were measured in 26 patients with non-insulin dependent diabetes mellitus (NIDDM), 26 healthy subjects with closely matching plasma triglyceride (TG) levels and 10 normolipidaemic healthy individuals. In addition, insulin mediated glucose uptake was measured in the NIDDM patients and the normolipidaemic subjects. Rates of NCET were significantly (P < 0.05) elevated in NIDDM patients compared with healthy normolipidaemic individuals but were similar to rates in healthy subjects with closely matching TG levels. In all groups of subjects plasma NCET was significantly (P < 0.001) correlated with plasma TG concentration. In NIDDM patients correlations between NCET and plasma glucose (r = 0.489, P = 0.011) independently of plasma TG levels, and glycated haemoglobin levels (r = 0.430, P = 0.028) were also recorded. Insulin mediated glucose uptake was unrelated to plasma NCET rates in the study. These data suggest that in NIDDM patients under good diabetic control elevated plasma NCET rates are mainly due to hypertriglyceridaemia and a specific and possibly stimulatory effect of diabetes on these rates may be seen only in patients with poorly controlled diabetes.
在26例非胰岛素依赖型糖尿病（NIDDM）患者、26例血浆甘油三酯（TG）水平紧密匹配的健康受试者以及10例血脂正常的健康个体中，测量了血浆中新合成的胆固醇酯从高密度脂蛋白（HDL）向极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）的转移（NCET）速率。此外，还测量了NIDDM患者和血脂正常受试者中胰岛素介导的葡萄糖摄取。与血脂正常的健康个体相比，NIDDM患者的NCET速率显著升高（P < 0.05），但与TG水平紧密匹配的健康受试者的速率相似。在所有受试者组中，血浆NCET与血浆TG浓度显著相关（P < 0.001）。在NIDDM患者中，还记录到NCET与血浆葡萄糖（r = 0.489，P = 0.011）以及糖化血红蛋白水平（r = 0.430，P = 0.028）之间的相关性，且独立于血浆TG水平。在该研究中，胰岛素介导的葡萄糖摄取与血浆NCET速率无关。这些数据表明，在糖尿病控制良好的NIDDM患者中，血浆NCET速率升高主要归因于高甘油三酯血症，并且只有在糖尿病控制不佳的患者中才可能出现糖尿病对这些速率的特定且可能具有刺激作用。
