Berman I, Kalinowski A, Berman S M, Lengua J, Green A I
Maimonides Medical Center, Brooklyn, NY.
Compr Psychiatry. 1995 Jan-Feb;36(1):6-10. doi: 10.1016/0010-440x(95)90092-a.
The goals of the study were to determine the prevalence of obsessive or compulsive (OC) symptoms among chronic schizophrenic patients, and to elucidate the level of function and course of illness in chronic schizophrenic patients with and without such symptoms. Therapists of 102 patients with DSM-III-R diagnoses of chronic schizophrenia reported on their patients' OC symptoms, level of function, and course of illness. Twenty-five percent of the chronic schizophrenic patients presented with significant OC symptoms. The OC schizophrenics had significantly earlier onsets of their illnesses, had spent more time in the hospital in the previous 5 years, and were judged by their therapists to have a lower level of capacity for age-appropriate function. In addition, such patients had been less often employed and less often married, and were more dependent on others. The poorer prognosis for schizophrenic patients with OC symptoms than for those without these symptoms suggests the need for new therapeutic strategies for such patients.
该研究的目的是确定慢性精神分裂症患者中强迫或强迫症状（OC）的患病率，并阐明有或无此类症状的慢性精神分裂症患者的功能水平和病程。102名被诊断为慢性精神分裂症的DSM-III-R患者的治疗师报告了他们患者的OC症状、功能水平和病程。25%的慢性精神分裂症患者出现明显的OC症状。患有OC症状的精神分裂症患者发病时间明显更早，在过去5年中住院时间更长，治疗师认为他们在适合年龄的功能方面能力水平较低。此外，这类患者就业和结婚的频率较低，且更依赖他人。有OC症状的精神分裂症患者的预后比无这些症状的患者更差，这表明需要为这类患者制定新的治疗策略。
