Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Psychiatry Res. 2017 Apr;250:277-284. doi: 10.1016/j.psychres.2017.01.067. Epub 2017 Jan 25.
The aim of this study was to evaluate the prevalence of comorbid obsessive compulsive symptoms/disorder and its impact on outcome among patients with schizophrenia. 181 patients with schizophrenia were evaluated on Yale-Brown Obsessive-Compulsive Symptom Checklist, Yale-Brown Obsessive-Compulsive Scale, Calgary Depression Scale for Schizophrenia, Positive and Negative Symptom Scale, Social Occupational Functioning Scale, Global Assessment of Functioning Scale and Indian Disability Evaluation and Assessment Scale. Slightly more than one-fourth of patients fulfilled the diagnosis of current (28.2%) and lifetime (29.8%) diagnosis of obsessive compulsive disorder. On Yale Brown Obsessive Compulsive Symptom Checklist, the most common lifetime obsessions were those of contamination (25.4%), followed by obsessions of need for symmetry or exactness (11.6%). The most common compulsions were those of cleaning/washing (27.1%), followed by those of checking (24.3%). Presence of obsessive compulsive symptoms was associated with younger age of onset, higher prevalence of comorbid depression, and current suicidal ideations. Thus, it can be concluded that a significant proportion of patients with schizophrenia have obsessive compulsive symptoms/disorder. Clinicians managing patients of schizophrenia should evaluate the patients thoroughly for presence of comorbid obsessive compulsive symptoms/disorder and must take the same into account while managing the patients.
本研究旨在评估精神分裂症患者中伴发强迫症状/障碍的患病率及其对结局的影响。对 181 例精神分裂症患者进行耶鲁-布朗强迫症状清单、耶鲁-布朗强迫量表、卡尔加里精神分裂症抑郁量表、阳性和阴性症状量表、社会职业功能量表、总体功能评估量表和印度残疾评估和评估量表评估。超过四分之一的患者符合当前(28.2%)和终身(29.8%)强迫症的诊断。在耶鲁布朗强迫症状清单上,最常见的终生强迫观念是被污染的观念(25.4%),其次是需要对称或精确的强迫观念(11.6%)。最常见的强迫行为是清洁/洗涤(27.1%),其次是检查(24.3%)。存在强迫症状与发病年龄较小、共患抑郁患病率较高和当前自杀意念有关。因此,可以得出结论,相当一部分精神分裂症患者存在强迫症状/障碍。治疗精神分裂症患者的临床医生应彻底评估患者是否存在共患强迫症状/障碍,并在治疗患者时必须考虑到这一点。