Creinin M D
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco General Hospital.
Contraception. 1994 Dec;50(6):511-5. doi: 10.1016/0010-7824(94)90010-8.
Methotrexate and misoprostol have been shown in preliminary studies to be effective for abortion at < or = 56 days gestation with minimal side effects. RU-486 is used in combination with prostaglandin for abortion < or = 49 days gestation in France but < or = 63 days gestation in England. This pilot study was performed to evaluate if methotrexate and misoprsotol may also be effective up to 63 days gestation. Ten pregnant women between 57-63 days gestation were treated with methotrexate 50 mg/m2 intramuscularly followed 3 days later by misoprostol 800 micrograms vaginally. Abortion occurred in 6 women; abortion occurred in one of the women after a repeat dose of misoprostol 24 hours after the first dose. The remaining 4 women all had a surgical abortion. In the successfully treated women, vaginal bleeding lasted 14 +/- 4 (mean +/- standard deviation) days and serum beta-hCG was < or = 25 IU/L by 32 +/- 5 days after the methotrexate injection. No methotrexate side effects occurred. Methotrexate and misoprostol do not appear to be as effective for medical abortion between 57 and 63 days gestation as compared to < or = 56 days gestation.
在初步研究中已表明，甲氨蝶呤和米索前列醇在妊娠≤56天时用于流产有效，且副作用最小。在法国，RU-486与前列腺素联合用于妊娠≤49天的流产，而在英国则用于妊娠≤63天的流产。本前瞻性研究旨在评估甲氨蝶呤和米索前列醇在妊娠达63天时是否也有效。10名妊娠57 - 63天的孕妇接受了甲氨蝶呤50mg/m²肌肉注射治疗，3天后阴道给予米索前列醇800μg。6名妇女发生流产；其中1名妇女在首次给药24小时后重复给予米索前列醇后流产。其余4名妇女均接受了手术流产。在成功治疗的妇女中，阴道出血持续14±4（均值±标准差）天，甲氨蝶呤注射后32±5天时血清β-hCG≤25IU/L。未出现甲氨蝶呤副作用。与妊娠≤56天相比，甲氨蝶呤和米索前列醇在妊娠57至63天时用于药物流产似乎效果不佳。
