一种释放醋酸炔诺酮和炔雌醇的避孕阴道环。

A contraceptive vaginal ring releasing norethindrone acetate and ethinyl estradiol.

作者信息

Ballagh S A, Mishell D R, Lacarra M, Shoupe D, Jackanicz T M, Eggena P

机构信息

University of Southern California School of Medicine, Department of Obstetrics and Gynecology, Los Angeles.

出版信息

Contraception. 1994 Dec;50(6):517-33. doi: 10.1016/0010-7824(94)90011-6.

DOI:10.1016/0010-7824(94)90011-6

PMID:7705095

Abstract

A core design contraceptive vaginal ring (CVR) releasing 650 mcg of norethindrone acetate (NA) and 10, 20, 30 or 65 mcg of ethinyl estradiol (EE) daily was developed and tested in 99 women. The CVR inhibited ovulation well with 30 or 65 mcg EE. Vaginal bleeding was better controlled than in 23 control women using NA/EE oral contraceptives. Side effects were comparable to controls for the 20 and 30 mcg EE CVR. The 65 mcg EE CVR resulted in an unacceptably high level of nausea. The 20 and 30 mcg EE CVR caused an increase in serum HDL cholesterol and triglycerides. Total cholesterol was unchanged. Angiotensinogen and sex hormone binding globulin-binding capacity were increased in a subgroup of the 20 and 30 mcg EE CVR subjects, similar to that of 20 controls using EE/gestodene oral contraceptives. This new CVR offers an excellent contraceptive alternative with the best performance provided by the 30 mcg EE dose.

摘要

研发了一种核心设计的避孕阴道环（CVR），其每日释放650微克醋酸炔诺酮（NA）和10、20、30或65微克炔雌醇（EE），并在99名女性中进行了测试。含30或65微克EE的CVR能很好地抑制排卵。与23名使用NA/EE口服避孕药的对照女性相比，CVR对阴道出血的控制效果更好。含20和30微克EE的CVR的副作用与对照组相当。含65微克EE的CVR导致恶心程度高得令人难以接受。含20和30微克EE的CVR使血清高密度脂蛋白胆固醇和甘油三酯增加。总胆固醇未改变。在含20和30微克EE的CVR受试者亚组中，血管紧张素原和性激素结合球蛋白结合能力增加，类似于20名使用EE/孕二烯酮口服避孕药的对照者。这种新型CVR提供了一种出色的避孕选择，其中含30微克EE剂量的CVR性能最佳。