Last J A, Sun W M, Witschi H
Department of Internal Medicine (Pulmonary Division), California Regional Primate Research Center, University of California, Davis 95616-8542.
Environ Health Perspect. 1994 Dec;102 Suppl 10(Suppl 10):179-84. doi: 10.1289/ehp.94102s10179.
This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled agents is also discussed. Newer studies are emphasized, especially those published in the last 5 years or still in press. Very recent data from our laboratory that suggest a new cellular mechanism of importance in lung injury in animals exposed to mixtures of ozone and NO2 that may have general relevance with regard to the effects of oxidant air pollutants on the lung are also presented.
本文综述了三种氧化性空气污染物臭氧、一氧化氮（NO）和二氧化氮（NO₂）的急性和慢性毒性。还讨论了NO₂与其他吸入剂二元混合物的毒性。重点介绍了较新的研究，特别是过去5年发表或仍在印刷中的研究。还展示了我们实验室最近的数据，这些数据表明在暴露于臭氧和NO₂混合物的动物肺损伤中一种新的重要细胞机制，这可能与氧化性空气污染物对肺的影响具有普遍相关性。
