Koenig J Q, Covert D S, Marshall S G, Van Belle G, Pierson W E
Department of Environmental Health, University of Washington, Seattle 98195.
Am Rev Respir Dis. 1987 Nov;136(5):1152-7. doi: 10.1164/ajrccm/136.5.1152.
The aim of this project was to investigate whether well-characterized asthmatic adolescent subjects were more sensitive to the inhaled effects of oxidant pollutants than were well-characterized healthy adolescent subjects. Ten healthy and 10 asthmatic subjects inhaled via a mouth-piece 0.12 or 0.18 ppm of ozone (O3) or nitrogen dioxide (NO2) or clean air for 30 min at rest followed by 10 min during moderate exercise (32.5 L/min) on a treadmill. The following pulmonary functional values were measured before and after exposure: peak flow, total respiratory resistance (RT), maximal flow at 50 and 75% of expired VC, and FEV1. After exercise exposure to 0.18 ppm O3, statistically significant increases were seen in RT in asthmatic and healthy adolescent subjects. No consistent changes were seen in either group after NO2 exposure. Also, no significant differences in response to oxidant pollutants between the 2 groups could be demonstrated. It was concluded that neither group was consistently sensitive to these pollutants.
本项目的目的是研究，与特征明确的健康青少年受试者相比，特征明确的哮喘青少年受试者是否对吸入的氧化性污染物影响更为敏感。10名健康受试者和10名哮喘受试者通过咬嘴吸入0.12或0.18 ppm的臭氧（O3）或二氧化氮（NO2），或在静息状态下吸入清洁空气30分钟，随后在跑步机上进行10分钟的适度运动（32.5升/分钟）。在暴露前后测量以下肺功能值：峰值流量、总呼吸阻力（RT）、呼出肺活量50%和75%时的最大流量，以及第一秒用力呼气量（FEV1）。在运动后暴露于0.18 ppm O3后，哮喘和健康青少年受试者的RT均出现统计学上的显著增加。在暴露于NO2后，两组均未出现一致的变化。此外，两组之间对氧化性污染物的反应没有显著差异。得出的结论是，两组对这些污染物均未表现出持续的敏感性。
