Gauchat J F, Henchoz S, Fattah D, Mazzei G, Aubry J P, Jomotte T, Dash L, Page K, Solari R, Aldebert D
Glaxo Institute for Molecular Biology, Plan les Ouates/Geneva, Switzerland.
Eur J Immunol. 1995 Mar;25(3):863-5. doi: 10.1002/eji.1830250335.
CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to be involved in the control of B cell proliferation, immunoglobulin class switching as well as in the activation of monocytes and T cells. We demonstrate that CD40L can also be expressed constitutively by eosinophils from an hypereosinophilic patient or, upon activation, by the eosinophilic cell line EOL-3 and normal blood eosinophils. Eosinophils were able to induce, in conjunction with IL-4, CD40L-dependent B cell proliferation in vitro. These results suggest that CD40L could play a role in the inflammatory processes during which eosinophil infiltration and activation are observed.
CD40配体（CD40L）是一种可由T细胞、肥大细胞和嗜碱性粒细胞表达的表面分子，已被证明参与B细胞增殖的调控、免疫球蛋白类别转换以及单核细胞和T细胞的激活。我们证明，CD40L也可由一名嗜酸性粒细胞增多症患者的嗜酸性粒细胞组成性表达，或者在激活后由嗜酸性粒细胞系EOL-3和正常血液嗜酸性粒细胞表达。嗜酸性粒细胞能够在体外与IL-4共同诱导依赖CD40L的B细胞增殖。这些结果表明，CD40L可能在观察到嗜酸性粒细胞浸润和激活的炎症过程中发挥作用。
