Petrella T, Rat P, Lizard G, Dusserre-Guion L, Poulard G, Michiels R
Laboratoire d'Anatomie Pathologique, CHU de Dijon.
Gastroenterol Clin Biol. 1994;18(11):1021-7.
The authors are reporting a case of papillary and cystic neoplasm of the pancreas. This rare malignant epithelial neoplasm occurs mostly in young women and has a more favorable prognosis than the adenocarcinoma. Radiologic investigations showed a well demarcated, heterogeneous, hypovascular mass. The histological study showed the proliferation of epithelial cells in a papillary pattern. The immunochemistry was negative for markers of adenocarcinoma but positive for vimentin, alpha-1-antitrypsin, alpha-1-antichymotrypsin and neuron specific enolase. Receptors of progesterone were also detected. By flow cytometric analysis, the tumours was hypoploid. The histogenesis of these tumours remained controversed. Ultrastructural details of the neoplastic cells suggest that these tumours originate from small duct cells; detection in several cases of markers for endocrine neoplasm suggests that they originate from primitive multipotential cells, that may show exocrine or endocrine differentiation.
作者报告了一例胰腺乳头囊性肿瘤。这种罕见的恶性上皮性肿瘤多见于年轻女性，预后比腺癌更好。影像学检查显示有一个边界清晰、不均匀、血供少的肿块。组织学研究显示上皮细胞呈乳头状增殖。免疫化学检测腺癌标志物为阴性，但波形蛋白、α-1抗胰蛋白酶、α-1抗糜蛋白酶和神经元特异性烯醇化酶为阳性。还检测到孕激素受体。通过流式细胞术分析，肿瘤为亚二倍体。这些肿瘤的组织发生仍存在争议。肿瘤细胞的超微结构细节表明这些肿瘤起源于小导管细胞；在几例病例中检测到内分泌肿瘤标志物提示它们起源于原始多能细胞，可能表现出外分泌或内分泌分化。
