Lunetta P, Piatti B, Ferrario D, Zuccoli E, Tricomi P, Rossi G
Servizio di Anatomia Patologica dell'Ospedale S. Anna, Como.
Pathologica. 1994 Apr;86(2):211-6.
Three cases of papillary cystic tumor of the pancreas (PCTP) are described. They were observed in two female patients aged 42 and 39, and in a male patient aged 55. A fine-needle ultrasound-guided aspiration biopsy was performed in the man. The cytologic and histologic features turned out to be diagnostic and in compliance with literature data. In the three cases immunohistochemical analyses showed positive reaction to vimentin and alpha-1-antitrypsin. Two cases expressed neuron-specific enolase. Ultrastructural examination revealed similarities between neoplastic cells and normal centroacinar cells of the pancreas. Flow cytometric study revealed a diploid G0/1 peak in two cases. The patients underwent wide surgical excision of the neoplasia. No recurrences or metastases are found with follow-up of 10 years, 8 years and 10 month respectively.
本文描述了三例胰腺乳头状囊性肿瘤（PCTP）。两名女性患者，年龄分别为42岁和39岁，以及一名55岁男性患者被观察到患有该疾病。对该男性患者进行了超声引导下细针穿刺活检。细胞学和组织学特征显示具有诊断意义，且与文献数据相符。在这三例病例中，免疫组化分析显示波形蛋白和α-1抗胰蛋白酶呈阳性反应。两例表达神经元特异性烯醇化酶。超微结构检查显示肿瘤细胞与胰腺正常中央腺泡细胞之间存在相似性。流式细胞术研究显示两例出现二倍体G0/1峰。患者均接受了肿瘤的广泛手术切除。分别随访10年、8年和10个月，均未发现复发或转移。
