Wurthmann C, Klieser E, Lehmann E
Psychiatrische Klinik, Otto-von-Guericke-Universität Magdeburg.
Fortschr Neurol Psychiatr. 1995 Feb;63(2):72-7. doi: 10.1055/s-2007-996605.
The present study was designed to investigate the interaction between therapeutic effects and side-effects in fluspirilene treatment of generalised anxiety disorders (GAD). 205 outpatients received in an open trial 1.5 mg fluspirilene per week for 6 weeks. Confirming previous reports of our study group fluspirilene demonstrated marked efficacy and was generally well tolerated. However, the main finding of our study is that side effects, although rare in fluspirilene treatment, predict an unfavourable clinical outcome. This phenomenon is integrated in a psychological model implying that when GAD patients are aware of side-effects this induces anxiety. Again anxiety gives rise to somatic symptoms, both interacting in a forward loop. In conclusion, our data suggest that in the sense of Heinrich (1988) fluspirilene treatment of GAD should be guided by paying attention to possible side effects.
本研究旨在探讨氟斯必灵治疗广泛性焦虑症（GAD）时治疗效果与副作用之间的相互作用。205名门诊患者在一项开放试验中，每周接受1.5毫克氟斯必灵治疗，为期6周。证实了我们研究组之前的报告，氟斯必灵显示出显著疗效，且总体耐受性良好。然而，我们研究的主要发现是，副作用虽然在氟斯必灵治疗中很少见，但预示着不良的临床结果。这一现象被整合到一个心理模型中，该模型表明，当GAD患者意识到副作用时，会引发焦虑。焦虑又会导致躯体症状，两者在前向循环中相互作用。总之，我们的数据表明，按照海因里希（1988年）的观点，氟斯必灵治疗GAD时应通过关注可能的副作用来进行指导。
