Diez-Ruiz A, Tilz G P, Gutierrez-Gea F, Gil-Extremera B, Murr C, Wachter H, Fuchs D
Department of Internal Medicine, University of Granada, Spain.
Hepatology. 1995 Apr;21(4):976-8. doi: 10.1002/hep.1840210414.
Alcohol-induced cirrhosis (AC) is accompanied by disturbances of immune function and cytokine production. To better define the pattern of cytokine synthesis in this disease and to relate it to the immune activation state, we measured circulating levels of soluble tumor necrosis factor receptor p55 (sTNFR-55) and neopterin in a group of 85 patients with AC (classified according to the Child-Pugh score of severity of liver disease) and 43 healthy volunteers. Serum concentrations of sTNFR-55 and neopterin were significantly raised in patients with AC. Moreover, concentrations of sTNFR-55 were significantly higher in patients with more severe disease compared with the group with lower severity. There were significant correlations between sTNFR-55 and neopterin levels in patients and controls. The results contribute to affirm the existence of an immune activation state in AC that could be responsible for the development of the disease and clinical complications.
酒精性肝硬化（AC）伴有免疫功能紊乱和细胞因子产生异常。为了更好地界定该疾病中细胞因子合成模式并将其与免疫激活状态相关联，我们检测了85例AC患者（根据肝病严重程度的Child-Pugh评分分类）和43名健康志愿者的循环中可溶性肿瘤坏死因子受体p55（sTNFR-55）和新蝶呤水平。AC患者的血清sTNFR-55和新蝶呤浓度显著升高。此外，病情较重的患者与病情较轻的患者相比，sTNFR-55浓度显著更高。患者和对照组中sTNFR-55与新蝶呤水平之间存在显著相关性。这些结果有助于证实AC中存在免疫激活状态，这可能是该疾病及其临床并发症发生的原因。
