Nassonov E L, Samsonov M Y, Tilz G P, Beketova T V, Semenkova E N, Baranov A, Wachter H, Fuchs D
Cardiology Research Center, Moscow Sechenov Medical Academy, Russia.
J Rheumatol. 1997 Apr;24(4):666-70.
To investigate the possible relationship between serum levels of neopterin, soluble tumor necrosis factor-55 receptor (sTNF-55R), and soluble interleukin 2 receptor (sIL-2R) with disease activity in patients with Wegener's granulomatosis (WG).
Serum neopterin was measured by radioimmunoassay, sTNF-55R and sIL-2R were measured by ELISA in 26 patients with WG.
Serum neopterin, sTNF-55R, and sIL-2R were significantly elevated in patients with generalized WG compared with healthy controls. Concentrations of the analytes correlated with disease activity indices in patients without infectious complications. The highest elevations of all 3 variables were observed in patients with intercurrent infections.
The increased serum levels of neopterin, sTNF-55R, and sIL-2R suggest activation of cellular immunity in WG.
探讨韦格纳肉芽肿（WG）患者血清中蝶呤、可溶性肿瘤坏死因子-55受体（sTNF-55R）和可溶性白细胞介素2受体（sIL-2R）水平与疾病活动度之间的可能关系。
采用放射免疫分析法测定26例WG患者血清中的蝶呤，采用酶联免疫吸附测定法测定sTNF-55R和sIL-2R。
与健康对照相比，全身性WG患者血清中的蝶呤、sTNF-55R和sIL-2R显著升高。在无感染并发症的患者中，这些分析物的浓度与疾病活动指数相关。在并发感染的患者中观察到所有3个变量的升高最为明显。
血清中蝶呤、sTNF-55R和sIL-2R水平升高提示WG患者细胞免疫激活。
