Lall S B, Peshin S S, Karmarkar M G
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
Indian J Physiol Pharmacol. 1995 Jan;39(1):51-4.
Plasma renin activity was determined in hundred normal subjects of either sex (M = 65, F = 35, age range 2-70 yr) using Angiotensin-I test kits. The effect of various physiological variables viz, age, sex, posture and salt intake was determined. The basal values for PRA ranged from 1.19 +/- 0.09 ng/ml/hr for males and 1.02 +/- 0.12 ng/ml/hr for females in erect posture. In contrast high basal supine PRA was noticed in subjects on low salt diet, which showed a significant increase in erect posture. A marked decrease in PRA with advancing age in both the sexes with significantly low values at higher age range was noticed. Captopril produced an insignificant effect on PRA and BP in salt replete supine state, whereas in salt deplete state there was a significant rise in both the parameters.
使用血管紧张素 I 检测试剂盒，对 100 名正常受试者（男性 65 名，女性 35 名，年龄范围 2 - 70 岁）测定血浆肾素活性。确定了各种生理变量，即年龄、性别、体位和盐摄入量的影响。立位时，男性血浆肾素活性（PRA）的基础值范围为 1.19±0.09 ng/ml/小时，女性为 1.02±0.12 ng/ml/小时。相比之下，低盐饮食的受试者仰卧位基础 PRA 较高，立位时显著升高。注意到随着年龄增长，两性的 PRA 均显著下降，在较高年龄范围时数值明显较低。在盐充足的仰卧状态下，卡托普利对 PRA 和血压的影响不显著，而在盐缺乏状态下，这两个参数均显著升高。
