Satyanarayana S, Krishna D M, Krishnaiah Y S, Visweswaram D
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam.
Indian J Physiol Pharmacol. 1995 Jan;39(1):71-3.
Acute treatment of rabbits with pargyline (50 mg/kg, ip, 30 min before tolbutamide) significantly increased the elimination half life and AUC0-->infinity of tolbutamide resulting in prolonged hypoglycaemia. Similar treatment also prolonged the half life of antipyrine which is used as model drug to indicate hepatic microsomal enzyme activity in vivo confirming that pargyline treatment delayed the elimination of tolbutamide in rabbits by inhibiting its hepatic metabolism.
用优降宁（50毫克/千克，腹腔注射，在甲苯磺丁脲给药前30分钟）对兔子进行急性处理，显著增加了甲苯磺丁脲的消除半衰期和AUC0→∞，导致低血糖持续时间延长。类似的处理也延长了安替比林的半衰期，安替比林用作模型药物以指示体内肝微粒体酶活性，证实优降宁处理通过抑制兔子肝脏代谢而延迟了甲苯磺丁脲的消除。
