Levi F, La Vecchia C, Randimbison L, Te V C
Registre vaudois des tumeurs, Institut universitaire de médecine sociale et préventive, Lausanne, Switzerland.
Int J Cancer. 1995 Mar 29;61(1):40-3. doi: 10.1002/ijc.2910610108.
Data from the Vaud Cancer Registry, Switzerland, were used to analyse incidence and mortality from cancer in teenagers (aged 10 to 19 years) over the period 1974-1992. A total of 113 males and 87 females were registered. Of these, 23% were lymphomas, 16% leukaemias, about 15% central nervous system neoplasms, 10% germ cell tumours and bone neoplasms and 8% soft tissue sarcomas. The overall incidence rate (age-adjusted, world standard population) for all cancers combined was 167 per million boys and 128 per million girls. In both sexes, there was some indication of rising trends over time, to reach 196 per million males and 141 per million females in 1986-1992. The only types of cancer showing consistent upward trends in both sexes were lymphomas. A total of 53 cancer deaths were certified, due to leukaemias in about 40% of cases in both sexes and to lymphomas and brain tumours in 15%-20%. The overall mortality rate at age 10-19 years (age-standardised, world standard) was 47 per million boys and 31 per million girls, and no trend in mortality was observed over time. The 2 main findings of our analysis are (i) the absence of major trends in cancer incidence in adolescents, with the sole exception of a possible increasing incidence of lymphomas, and (ii) the lack of appreciable trends in mortality, in view of the declines in cancer mortality observed in children and young adults over the same calendar period.
瑞士沃州癌症登记处的数据被用于分析1974年至1992年期间青少年（10至19岁）的癌症发病率和死亡率。总共登记了113名男性和87名女性。其中，23%为淋巴瘤，16%为白血病，约15%为中枢神经系统肿瘤，10%为生殖细胞瘤和骨肿瘤，8%为软组织肉瘤。所有癌症合并的总体发病率（年龄调整后，世界标准人口）为每百万男孩167例，每百万女孩128例。在两性中，都有一些随时间上升趋势的迹象，在1986 - 1992年达到每百万男性196例，每百万女性141例。在两性中显示出持续上升趋势的唯一癌症类型是淋巴瘤。总共认证了53例癌症死亡病例，约40%的病例死于白血病，15% - 20%死于淋巴瘤和脑肿瘤。10至19岁的总体死亡率（年龄标准化，世界标准）为每百万男孩47例，每百万女孩31例，且未观察到死亡率随时间的趋势。我们分析的两个主要发现是：（i）青少年癌症发病率没有主要趋势，唯一的例外是淋巴瘤发病率可能增加；（ii）鉴于在同一时期儿童和年轻人中癌症死亡率有所下降，死亡率没有明显趋势。
