Miller J M, Hall H L, Greivenkamp J E, Guyton D L
Department of Ophthalmology, University of Arizona, Tucson, USA.
Invest Ophthalmol Vis Sci. 1995 Apr;36(5):897-905.
To measure quantitatively the change in the coaxial fundus reflex with varying degrees of ocular misalignment.
The coaxial fundus reflex was imaged with a charge coupled device camera under conditions of simulated ocular misalignment ranging from 0 degrees to 7 degrees of fixation eccentricity. The effects of refractive error and pupil size were controlled. Average gray scale brightness values were calculated for each bright pupil image after some image processing was performed on the raw images.
A reliable, sharply delineated, minimum brightness at foveal fixation was observed.
It is estimated that this technique can be automated to detect the presence of 2 degrees to 3 degrees of ocular misalignment based on the difference in brightness of the bright pupil images between the two eyes.
定量测量不同程度眼位偏斜时同轴眼底反射的变化。
在模拟眼位偏斜（固定偏心度从0度到7度）的条件下，使用电荷耦合器件相机对同轴眼底反射进行成像。控制屈光不正和瞳孔大小的影响。对原始图像进行一些图像处理后，计算每个亮瞳孔图像的平均灰度亮度值。
观察到在中央凹注视时存在可靠的、轮廓清晰的最小亮度。
据估计，基于双眼亮瞳孔图像亮度差异，该技术可实现自动化，以检测2度至3度的眼位偏斜。
