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单次吸入高浓度二氧化碳抗焦虑作用的对手过程解释。

An opponent-process interpretation of the anxiolytic effects of single inhalations of large concentrations of carbon dioxide.

作者信息

Ley R

机构信息

University at Albany, State University of New York 12222.

出版信息

J Behav Ther Exp Psychiatry. 1994 Dec;25(4):301-9. doi: 10.1016/0005-7916(94)90038-8.

DOI:10.1016/0005-7916(94)90038-8
PMID:7706507
Abstract

Ten anxiety-disorder outpatients and 10 controls were monitored for heart rate and self reports of anxiety approximately 1 min before and 1 min after a single full-capacity inhalation of a gas consisting of either 65% CO2 + 35% O2 or compressed air. Under the CO2 + O2 condition, patients and controls showed almost identical reductions in anxiety and parallel reductions in heart rate. From an opponent-process point of view, these reductions were explained by the acute negative affective state being followed by the hedonically pleasant state that follows dissipation of CO2. Under the compressed air condition, only patients showed reductions of anxiety presumably because in them breathing an unknown gas via an inhalation mask, raised anxiety, followed by an opponent-process to anxiety after withdrawal of the mask.

摘要

对10名焦虑症门诊患者和10名对照组人员进行了心率监测,并在单次全量吸入由65%二氧化碳+35%氧气组成的气体或压缩空气之前约1分钟和之后约1分钟收集焦虑自评报告。在二氧化碳+氧气条件下,患者和对照组的焦虑水平几乎同等程度降低,心率也同步下降。从对抗过程的角度来看,这些降低是由于急性负面情绪状态之后伴随着二氧化碳消散后的愉悦状态。在压缩空气条件下,只有患者的焦虑水平降低,大概是因为他们通过吸入面罩呼吸未知气体时会增加焦虑,而在撤下面罩后会出现对抗焦虑的过程。

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