van de Borne P, Schintgen M, Niset G, Schoenfeld P, Nguyen H, Degré S, Degaute J P
Hypertension Clinic, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
J Hypertens. 1994 Dec;12(12):1395-403.
To explore the repercussion of cardiac denervation on the short-term blood pressure variability in humans, in order to assess the extent to which the variability of blood pressure is linked to the variability of heart rate.
Beat-to-beat blood pressure and RR interval time were recorded in 16 heart-transplanted patients and were compared with those of 10 healthy control subjects in the resting supine, sitting and standing positions. Blood pressure and RR interval variabilities were assessed by spectral analysis.
The total blood pressure power and the sitting very low-frequency, low-frequency, low-frequency and high-frequency blood pressure variability were similar in the heart-transplanted patients and in the controls, despite a marked reduction in the RR interval variability in the heart-transplanted patients. However, the heart-transplanted patients had lower standing low-frequency blood pressure variability than the control subjects. Moreover, very low-frequency and low-frequency RR interval variabilities reappeared in the long-term heart-transplanted patients but not in the short-term heart-transplanted patients (range of time after transplantation 53-124 and 3-25 months, respectively).
Short-term RR interval fluctuations are not mandatory for the maintenance of normal blood pressure variability in the supine and sitting positions, but may contribute to the increase in the low-frequency blood pressure variability which occurs normally in the standing position. Moreover, the long-term heart-transplanted patients had increased RR interval variability, which may have been caused by the reappearance of limited autonomic cardiac modulation. However, this increased RR interval variability did not affect the corresponding blood pressure variability.
探讨心脏去神经支配对人体短期血压变异性的影响，以评估血压变异性与心率变异性的关联程度。
记录16例心脏移植患者的逐搏血压和RR间期，并与10名健康对照者在静息仰卧位、坐位和站立位时的情况进行比较。通过频谱分析评估血压和RR间期变异性。
尽管心脏移植患者的RR间期变异性显著降低，但心脏移植患者和对照组的总血压功率以及坐位时的极低频、低频、低频和高频血压变异性相似。然而，心脏移植患者站立时的低频血压变异性低于对照者。此外，长期心脏移植患者的极低频和低频RR间期变异性重新出现，而短期心脏移植患者则未出现（移植后时间范围分别为53 - 124个月和3 - 25个月）。
短期RR间期波动对于维持仰卧位和坐位时的正常血压变异性并非必需，但可能有助于正常站立位时出现的低频血压变异性增加。此外，长期心脏移植患者的RR间期变异性增加，这可能是由于有限的自主心脏调节重新出现所致。然而，这种增加的RR间期变异性并未影响相应的血压变异性。
