Rivas M, Binsztein N, Basanta G, Vergara M, Quiroga M, Cinto R, Svennerholm A M
Instituto Nacional de Microbiologia Carlos G. Malbran, Buenos Aires, Argentina.
J Infect Dis. 1995 Apr;171(4):1045-9. doi: 10.1093/infdis/171.4.1045.
Serum antibody responses against Escherichia coli heat-labile enterotoxin (LT) and colonization factor antigens (CFAs) I and II were studied in 84 children < 5 years old living in two communities. These villages differed in the quality of their drinking water. Children from both communities developed significantly increased antibody titers against LT and CFA/II but not against CFA/I during 3 months of follow-up. The magnitude of the anti-LT response was significantly higher in children from Zaiman than in those from Las Dolores. Antibody titers rose to maximum levels during the second year of age and reached relatively constant levels in children aged 2-5 years, probably due to repeated exposure to enterotoxigenic E. coli strains. Antibody levels of 30 children were followed for 2 years; increases in anti-LT and anti-CFA titers varied in the different age groups.
对生活在两个社区的84名5岁以下儿童的血清抗大肠杆菌不耐热肠毒素（LT）以及定居因子抗原（CFA）I和II的抗体反应进行了研究。这两个村庄的饮用水质量不同。在3个月的随访期间，两个社区的儿童针对LT和CFA/II的抗体滴度均显著升高，但针对CFA/I的抗体滴度未升高。扎伊曼村儿童的抗LT反应强度显著高于拉斯多洛雷斯村的儿童。抗体滴度在儿童2岁时升至最高水平，并在2至5岁的儿童中达到相对稳定的水平，这可能是由于反复接触产肠毒素大肠杆菌菌株所致。对30名儿童的抗体水平进行了2年的跟踪；不同年龄组中抗LT和抗CFA滴度的升高情况各不相同。
