绝经后女性激素细胞学与骨密度关系的研究

[Study on the relationship between hormonal cytology and bone mineral density in postmenopausal women].

作者信息

Yasuda M, Kurabayashi T, Yamamoto Y, Fujimaki T, Oda K, Minagawa Y, Kodama S, Tanaka K

机构信息

Department of Obstetrics and Gynecology, Niigata University School of Medicine.

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1995 Feb;47(2):157-62.

PMID:7706856

Abstract

We assessed the relationship between bone mineral density (BMD) and hormonal cytology in 181 postmenopausal women. BMD was measured by dual energy X-ray absorptiometry (DXA). Age, height, weight, body mass index (BMI), age at menopause, hormonal cytology (eosinophilic index (EI), karyopyknotic index (KPI) and maturation value (MV)) and estradiol were investigated. A positive correlation was found between BMD and hormonal cytology (EI r = 0.17 p < 0.05, KPI r = 0.19 p < 0.05 and MV r = 0.37 p < 0.005). The low BMD group (BMD < 0.8g/cm2 n = 87) had significantly lower hormonal cytology than the normal BMD group (BMD > or = 0.8g/cm2 n = 94). The receiver operating characteristic curve analysis showed MV at 30 was available for the cutoff point in predicting osteopenia. MV < 30 detected osteopenia (BMD < 0.8g/cm2) as 0.76 in sensitivity and 0.65 in specificity. These findings suggest that hormonal cytology is useful for screening osteopenia in post-menopausal women.

摘要

我们评估了181名绝经后女性的骨矿物质密度（BMD）与激素细胞学之间的关系。采用双能X线吸收法（DXA）测量BMD。研究了年龄、身高、体重、体重指数（BMI）、绝经年龄、激素细胞学（嗜酸性指数（EI）、核固缩指数（KPI）和成熟值（MV））以及雌二醇。发现BMD与激素细胞学之间存在正相关（EI r = 0.17，p < 0.05；KPI r = 0.19，p < 0.05；MV r = 0.37，p < 0.005）。低BMD组（BMD < 0.8g/cm²，n = 87）的激素细胞学显著低于正常BMD组（BMD ≥ 0.8g/cm²，n = 94）。受试者工作特征曲线分析显示，MV为30时可作为预测骨质减少的临界点。MV < 30检测骨质减少（BMD < 0.8g/cm²）的灵敏度为0.76，特异度为0.65。这些发现表明，激素细胞学有助于筛查绝经后女性的骨质减少。