作为外源基因递送载体的泰勒氏病毒。
Theiler's virus as a vector for foreign gene delivery.
作者信息
Zhang L, Sato S, Kim J I, Roos R P
机构信息
Department of Neurology, University of Chicago Medical Center, Illinois 60637, USA.
出版信息
J Virol. 1995 May;69(5):3171-5. doi: 10.1128/JVI.69.5.3171-3175.1995.
Abstract
DA strain and other strains of the TO subgroup of Theiler's murine encephalomyelitis viruses are members of the Cardiovirus genus of picornaviruses and produce a persistent demyelinating disease in mice. A recent study from our laboratory (W.-P. Kong, G. D. Ghadge, and R. P. Roos, Proc. Natl. Acad. Sci. USA 91:1796-1800, 1994) demonstrated that the leader, which is encoded at the N terminus of the Theiler's murine encephalomyelitis virus polyprotein, can be partially replaced by foreign sequences as well as completely deleted, with no loss of infectivity in BHK-21 cells. In this study, we have inserted up to 724 nucleotides into the leader coding region of an infectious DA clone. Recombinant viruses were produced, and the inserts were shown to be stable for at least three passages in BHK-21 cells.
摘要
泰勒氏鼠脑脊髓炎病毒TO亚组的DA毒株及其他毒株属于小核糖核酸病毒科心病毒属成员，可在小鼠中引发持续性脱髓鞘疾病。我们实验室最近的一项研究（W.-P. 孔、G. D. 加德格和R. P. 鲁斯，《美国国家科学院院刊》91:1796 - 1800, 1994）表明，位于泰勒氏鼠脑脊髓炎病毒多聚蛋白N端编码的前导序列，可被外源序列部分取代或完全缺失，而在BHK - 21细胞中不丧失感染性。在本研究中，我们在一个感染性DA克隆的前导编码区插入了多达724个核苷酸。产生了重组病毒，并且这些插入片段在BHK - 21细胞中至少传代三次后仍保持稳定。
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