减毒门戈病毒：一种用于活重组疫苗的新型载体。
Attenuated Mengo virus: a new vector for live recombinant vaccines.
作者信息
Altmeyer R, Girard M, van der Werf S, Mimic V, Seigneur L, Saron M F
机构信息
Unité de Virologie Moléculaire, Institut Pasteur, Paris, France.
出版信息
J Virol. 1995 May;69(5):3193-6. doi: 10.1128/JVI.69.5.3193-3196.1995.
Abstract
Several features make Mengo virus an excellent candidate for use as a vaccine vector. The virus has a wide host range, including rodents, pigs, monkeys, and most likely humans, and expresses its genome exclusively in the cytoplasm of the infected cell. Stable attenuated strains exist which are deleted for part of the 5' noncoding region of the genome. Here we report an attenuated Mengo virus recombinant, vLCMG4, that encodes an immunodominant cytotoxic T-lymphocyte epitope of the lymphocytic choriomeningitis virus (LCMV) nucleo-protein. vLCMG4 induced protective immunity against lethal LCMV infection after a single, low-dose immunization in BALB/c mice and elicited an LCMV-specific CD8+ cytotoxic T lymphocyte response. This demonstrates the potential of recombinant Mengo virus vaccines to confer protection against infectious diseases by the induction of cellular immune responses.
摘要
有几个特征使门戈病毒成为用作疫苗载体的理想候选者。该病毒具有广泛的宿主范围，包括啮齿动物、猪、猴子，很可能还包括人类，并且其基因组仅在受感染细胞的细胞质中表达。存在稳定的减毒株，其基因组的5'非编码区的一部分被缺失。在此，我们报告一种减毒的门戈病毒重组体vLCMG4，它编码淋巴细胞性脉络丛脑膜炎病毒（LCMV）核蛋白的一个免疫显性细胞毒性T淋巴细胞表位。vLCMG4在BALB/c小鼠中单次低剂量免疫后诱导了针对致死性LCMV感染的保护性免疫，并引发了LCMV特异性CD8+细胞毒性T淋巴细胞反应。这证明了重组门戈病毒疫苗通过诱导细胞免疫反应来提供针对传染病的保护的潜力。
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2
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3
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4
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5
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6
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7
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8
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