1型人类免疫缺陷病毒原发性综合征中细胞免疫反应与病毒血症初始控制的时间关联。
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.
作者信息
Koup R A, Safrit J T, Cao Y, Andrews C A, McLeod G, Borkowsky W, Farthing C, Ho D D
机构信息
Aaron Diamond AIDS Research Center, New York University School of Medicine, New York 10016.
出版信息
J Virol. 1994 Jul;68(7):4650-5. doi: 10.1128/JVI.68.7.4650-4655.1994.
Abstract
Virologic and immunologic studies were performed on five patients presenting with primary human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) precursors specific for cells expressing antigens of HIV-1 Gag, Pol, and Env were detected at or within 3 weeks of presentation in four of the five patients and were detected in all five patients by 3 to 6 months after presentation. The one patient with an absent initial CTL response had prolonged symptoms, persistent viremia, and low CD4+ T-cell count. Neutralizing antibody activity was absent at the time of presentation in all five patients. These findings suggest that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and indicate a role for CTL in protective immunity to HIV-1 in vivo.
摘要
对5例原发性人类免疫缺陷病毒1型（HIV-1）感染患者进行了病毒学和免疫学研究。在5例患者中的4例就诊时或就诊后3周内检测到了针对表达HIV-1 Gag、Pol和Env抗原的细胞的CD8+细胞毒性T淋巴细胞（CTL）前体，就诊后3至6个月时在所有5例患者中均检测到。1例初始CTL反应缺失的患者症状持续时间延长、病毒血症持续存在且CD4+ T细胞计数较低。所有5例患者就诊时均无中和抗体活性。这些发现表明，细胞免疫参与了原发性HIV-1感染中病毒复制的初始控制，并提示CTL在体内对HIV-1的保护性免疫中发挥作用。
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