Cadet J L, Kahler L A
Molecular Neuropsychiatry Section, NIH/NIDA, Baltimore, MD 21224.
Neurosci Biobehav Rev. 1994 Winter;18(4):457-67. doi: 10.1016/0149-7634(94)90001-9.
The present article discusses the distribution of free radical processes in the central nervous system (CNS). Specifically, we discuss the involvement of oxyradicals in the normal metabolism of catecholamine. We also review some proposals related to the possible importance of these compounds in the development of neuropsychiatric and movement disorders such as schizophrenia and neuroleptic-induced tardive dyskinesia (TD), respectively. Clinical studies have shown that antioxidant treatment can attenuate the movement abnormalities observed in TD. Further studies are necessary to evaluate the status of specific scavenging systems in these two disorders. The prophylactic use of antioxidants in patients who are treated with neuroleptics needs also to be considered.
本文讨论了自由基过程在中枢神经系统（CNS）中的分布。具体而言，我们讨论了氧自由基在儿茶酚胺正常代谢中的作用。我们还回顾了一些有关这些化合物在神经精神疾病和运动障碍（如精神分裂症和抗精神病药物所致迟发性运动障碍（TD））发展中可能重要性的提议。临床研究表明，抗氧化治疗可减轻TD中观察到的运动异常。有必要进一步研究以评估这两种疾病中特定清除系统的状态。还需要考虑在接受抗精神病药物治疗的患者中预防性使用抗氧化剂。
