Morera-Fumero Armando L, Abreu-Gonzalez Pedro
Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, University of La Laguna, 38071 La Laguna, Spain.
Int J Mol Sci. 2013 Apr 25;14(5):9037-50. doi: 10.3390/ijms14059037.
Schizophrenia is a chronic mental disease that disturbs several cognitive functions, such as memory, thought, perception and volition. Schizophrenia's biological etiology is multifactorial and is still under investigation. Melatonin has been involved in schizophrenia since the first decades of the twentieth century. Research into melatonin regarding schizophrenia has followed two different approaches. The first approach is related to the use of melatonin as a biological marker. The second approach deals with the clinical applications of melatonin as a drug treatment. In this paper, both aspects of melatonin application are reviewed. Its clinical use in schizophrenia is emphasized.
精神分裂症是一种慢性精神疾病，会扰乱多种认知功能，如记忆、思维、感知和意志。精神分裂症的生物学病因是多因素的，仍在研究中。自20世纪头几十年以来，褪黑素就与精神分裂症有关。关于精神分裂症的褪黑素研究有两种不同的方法。第一种方法与将褪黑素用作生物标志物有关。第二种方法涉及褪黑素作为药物治疗的临床应用。本文综述了褪黑素应用的两个方面。重点强调了其在精神分裂症中的临床应用。
