寻找抗梭曼中毒的疗法。

Search for a therapy against soman-intoxication.

作者信息

Wolthuis O L, van Helden H P, Melchers B P, Busker R W, de Groot D M

机构信息

Medical Biological Laboratory TNO Lange Kleiweg 139, Rijswijk, The Netherlands.

出版信息

Neurosci Biobehav Rev. 1994 Winter;18(4):469-86. doi: 10.1016/0149-7634(94)90002-7.

DOI:10.1016/0149-7634(94)90002-7

PMID:7708361

Abstract

This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. In particular soman, because this is one of the nerve agents that consistently appears to be very resistant to treatment. Various experimental approaches are described. Yet, even after all these years of research an adequate (pre)treatment against poisoning by soman is still not available.

摘要

本综述主要描述了过去几十年间我们实验室开展的部分药理学研究，旨在寻找针对胆碱酯酶抑制性有机磷酸酯中毒的治疗方法，尤其是针对神经毒剂梭曼。特别提及梭曼，是因为它是一直以来似乎对治疗极具抗性的神经毒剂之一。文中描述了各种实验方法。然而，即便经过这么多年的研究，针对梭曼中毒的充分（预）治疗方法仍未找到。