[Epidermal keratinocyte proliferation, differentiation and apoptosis in the posttraumatic skin regeneration of rats with different initial reactivities].

After the skin damage against the background of general deep prolonged hypothermia its organotypic regeneration took place with de novo formation of hairs and sebaceous glands. In certain periods of the wound process, the mitotic activity of keratinocytes was markedly higher than the rate of their apoptosis, thus providing for sharp thickening of the regenerating epidermis. No such phenomena were observed in the rats that were wounded under the normal thermal conditions. Instead a scar was formed in the place of regenerate. Accumulation of keratohyalin in granules in the epidermis granular layer and formation of a horny layer in the normothermic animals started earlier than in the cooled rats. Delay of differentiation of the keratinocytes, as well as marked predominance of the mitotic activity over the apoptosis rate in the regenerating epidermis of the cooled rats could induce organotypic skin regeneration.