[Conditions for organotypic skin regeneration in wounding during general deep hypothermia of the body].

The experiments on 150 albino rats studied the specific features of the natural history of a wounding process when a wound is made during long-term deep hypothermia of the body. A skin-type regenerate has been found to be formed. A connective tissue scar has been detected in the controls. There is a delayed occurrence of leukocytic, macrophage, and fibroblastic phases of inflammation. The rate of angiogenesis in the regenerate was decreased early and activated late during a wounding process. There were higher counts of mast cells 5, 15, 20, and 30 days after injury. The counts of lymphocytes in the regenerate were lower 1, 3, 5, and 10 days and higher 15 days. The specific marked features of the wounding process could be a cause of organotypic skin regeneration.