Spector D
Cancer Pain Services, Mt. Sinai Comprehensive Cancer Center, Miami Beach, FL.
Oncol Nurs Forum. 1995 Jan-Feb;22(1):97-101.
PURPOSE/OBJECTIVES: To describe the pathogenesis, clinical manifestations, and diagnosis of transfusion-associated graft-versus-host disease (TA-GVHD) and to illustrate these concepts using two case reports.
Published articles, books, and the author's clinical experience.
Graft-versus-host disease (GVHD) is most commonly associated with allogeneic bone marrow transplantation (BMT). However, GVHD increasingly is being reported in the non-BMT population. Of particular concern is TA-GVHD, an underrecognized, usually life-threatening complication of supportive care in both immunosuppressed as well as immunocompetent hosts.
Most cases of TA-GVHD may be prevented with the use of irradiated blood products.
Nurses can have a positive impact on the prevention of this highly morbid disease. Thorough assessment, education, and supportive care are essential when caring for patients with TA-GVHD. Because of ineffective treatment strategies, is-sues surrounding death and dying cannot be overlooked.
目的/目标：描述输血相关移植物抗宿主病（TA-GVHD）的发病机制、临床表现及诊断，并通过两例病例报告阐述这些概念。
已发表的文章、书籍及作者的临床经验。
移植物抗宿主病（GVHD）最常与异基因骨髓移植（BMT）相关。然而，非BMT人群中GVHD的报道日益增多。特别值得关注的是TA-GVHD，这是一种在免疫抑制宿主和免疫功能正常宿主的支持性治疗中未得到充分认识、通常危及生命的并发症。
使用辐照血液制品可预防大多数TA-GVHD病例。
护士对预防这种高致死性疾病可产生积极影响。护理TA-GVHD患者时，全面评估、教育及支持性护理至关重要。由于治疗策略无效，围绕死亡和临终的问题不容忽视。
