Ohto H, Suzuki H, Abe R
Blood Transfusion Service, Fukushima Medical College, Japan.
Fukushima J Med Sci. 1993 Dec;39(2):63-7.
In order to devise the way of prevention and the progress in the treatment of transfusion-associated graft-versus-host disease (TA-GVHD), this issue is published as the results of the symposium on GVHD at Fukushima Medical College, 1992. HLA analyses of TA-GVHD forced us to alter our concept of mechanism of this disease. As one-way matching in HLA from donor to recipient is important in developing the TA-GVHD, transfusions between relatives are most hazardous and there is a higher risk even unrelated donors in Japanese. Prophylactic irradiation of blood components is the method of inactivating immunocompetent lymphocytes and is nowadays the most effective in preventing the TA-GVHD. In the future we will have leukocyte depletion filters of next generation and ultraviolet irradiation on platelet concentrates as alternative to irradiation.
为了探寻输血相关移植物抗宿主病（TA-GVHD）的预防方法及治疗进展，本期发表了1992年福岛医学院GVHD研讨会的成果。对TA-GVHD的HLA分析促使我们改变了对这种疾病发病机制的认识。由于供体与受体之间HLA的单向匹配在TA-GVHD的发生中很重要，亲属间输血最为危险，而且在日本即使是无关供体也有较高风险。对血液成分进行预防性照射是灭活免疫活性淋巴细胞的方法，目前是预防TA-GVHD最有效的方法。未来我们将有下一代白细胞去除滤器以及对血小板浓缩物进行紫外线照射作为照射的替代方法。
