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动脉内注射载有阿霉素的白蛋白微球用于局部晚期乳腺癌。

Intra-arterial administration of adriamycin-loaded albumin microspheres for locally advanced breast cancer.

作者信息

Doughty J C, Anderson J H, Willmott N, McArdle C S

机构信息

University Department of Surgery, Royal Infirmary, Glasgow, UK.

出版信息

Postgrad Med J. 1995 Jan;71(831):47-9. doi: 10.1136/pgmj.71.831.47.

DOI:10.1136/pgmj.71.831.47
PMID:7708595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2397896/
Abstract

Regional chemotherapy is an attractive but underevaluated method of treating locally advanced breast cancer. We have combined two novel methods of targeting by delivering a single pulse of adriamycin-loaded albumin microspheres down a radiologically placed internal mammary artery catheter. A complete response was observed and prolonged local control achieved.

摘要

区域化疗是一种治疗局部晚期乳腺癌的有吸引力但未得到充分评估的方法。我们通过经放射定位的内乳动脉导管注入单脉冲阿霉素负载白蛋白微球，将两种新型靶向方法结合起来。观察到完全缓解并实现了长期局部控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2397896/86845d78e69c/postmedj00025-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2397896/766489d9a432/postmedj00025-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2397896/86845d78e69c/postmedj00025-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2397896/766489d9a432/postmedj00025-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2397896/86845d78e69c/postmedj00025-0051-a.jpg

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本文引用的文献

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Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy.
Br J Surg. 1988 Feb;75(2):132-4. doi: 10.1002/bjs.1800750214.
2
Locally advanced breast cancer: the contribution of cytotoxic and endocrine treatment to radiotherapy. An EORTC Breast Cancer Co-operative Group Trial (10792).局部晚期乳腺癌：细胞毒性和内分泌治疗对放疗的作用。一项欧洲癌症研究与治疗组织乳腺癌协作组试验（10792）。
Eur J Cancer Clin Oncol. 1989 Apr;25(4):667-78. doi: 10.1016/0277-5379(89)90203-4.
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Relationship between reductive drug metabolism in tumour tissue of anthracyclines in microspherical form and anti-tumour activity.
Biochem Pharmacol. 1990 Mar 15;39(6):1055-62. doi: 10.1016/0006-2952(90)90284-r.
包裹于聚（d，l-丙交酯-共-乙交酯）微球中的抗体诱导的独特型级联反应的抗肿瘤作用
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Br J Cancer. 1996 Nov;74(10):1545-52. doi: 10.1038/bjc.1996.587.
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Toxicity of intra-arterial doxorubicin in locally advanced breast cancer.局部晚期乳腺癌动脉内注射阿霉素的毒性
Cancer Chemother Pharmacol. 1990;25(6):459-62. doi: 10.1007/BF00686060.
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Treatment of locally advanced breast cancer.局部晚期乳腺癌的治疗
Semin Oncol. 1992 Jun;19(3):278-85.
6
An in vivo assessment of adriamycin-loaded albumin microspheres.阿霉素负载白蛋白微球的体内评估。
Br J Cancer. 1992 Mar;65(3):393-5. doi: 10.1038/bjc.1992.79.
7
[A case of complete response of locally advanced breast cancer to arterial infusion chemotherapy: cannulation through the right femoral artery and combined use of G-CSF].局部晚期乳腺癌对动脉灌注化疗完全缓解1例：经右股动脉插管及联合使用粒细胞集落刺激因子
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1625-7.