Ganassini A, Cazzadori A
Department of Respiratory Medicine, Ospedale Civile Maggiore, Verona, Italy.
Respir Med. 1995 Feb;89(2):143-5. doi: 10.1016/0954-6111(95)90198-1.
Invasive pulmonary aspergillosis is a frequent complication in immunocompromised patients. The role of the prolonged use of steroids in predisposing to invasive aspergillosis has been recognized, but exceptionally described in asthmatic patients. We report the case of a 59-year-old woman with bronchial asthma treated with steroid therapy for a long time, who developed an invasive pulmonary aspergillosis with an unusual combination of invasive and allergic disease. It seems reasonable to think that allergic disease due to allergic bronchopulmonary aspergillosis (ABPA) preceded the terminal invasive process. Adjunctive therapy with antifungal agents in patients with ABPA is considered, since there is the risk of an invasive pulmonary aspergillosis.
侵袭性肺曲霉病是免疫功能低下患者常见的并发症。长期使用类固醇激素在易患侵袭性曲霉病方面的作用已得到认可，但在哮喘患者中鲜有报道。我们报告了一例59岁的女性支气管哮喘患者，长期接受类固醇治疗，发生了侵袭性肺曲霉病，其侵袭性和过敏性疾病的组合不同寻常。似乎有理由认为，过敏性支气管肺曲霉病（ABPA）引起的过敏性疾病先于最终的侵袭过程。鉴于存在侵袭性肺曲霉病的风险，对于ABPA患者考虑使用抗真菌药物进行辅助治疗。
