Widders P R, Warner S, Huntington P J
Victorian Institute of Animal Science, Attwood, Australia.
Res Vet Sci. 1995 Jan;58(1):75-81. doi: 10.1016/0034-5288(95)90093-4.
Normal mares were immunised by the intramuscular and intrauterine administration of an antigen with adjuvant and they and unimmunised control mares were later challenged by the intrauterine instillation of pathogenic Streptococcus zooepidemicus; the response of all the mares was monitored clinically and bacteriologically for seven days. Significantly fewer S zooepidemicus were present in cervical swabs taken from the immunised mares than from the control mares (P < 0.01) and the degree of inflammation in the genital tract of the immunised mares was also significantly less (P < 0.001). This protective effect of immunisation was associated with the specific IgG response in the serum, and an IgG and IgA response in the uterine secretions. These results are the first demonstration that a previous immunisation with a suitable antigen can reduce an infection of the reproductive tract of mares.
用抗原与佐剂通过肌肉注射和子宫内给药对正常母马进行免疫，随后通过子宫内滴注致病性马链球菌对免疫母马和未免疫的对照母马进行攻毒；对所有母马的反应进行了为期7天的临床和细菌学监测。从免疫母马采集的宫颈拭子中存在的马链球菌明显少于对照母马（P < 0.01），免疫母马生殖道的炎症程度也明显较轻（P < 0.001）。免疫的这种保护作用与血清中的特异性IgG反应以及子宫分泌物中的IgG和IgA反应有关。这些结果首次证明，先前用合适的抗原进行免疫可以减少母马生殖道感染。
