Riikonen S, Saijonmaa O, Järvenpää A L, Fyhrquist F
Department of Medicine, Helsinki City Maternity Hospital, Finland.
Scand J Clin Lab Invest. 1994 Dec;54(8):653-7. doi: 10.3109/00365519409087546.
We have found serum erythropoietin (EPO) concentration significantly (p < 0.01) increased during normal pregnancy. Erythropoietin concentration was significantly (p < 0.05) higher before the 24th gestational week than after it. In pregnant women with iron deficiency anaemia serum EPO concentration was significantly (p < 0.001) higher than in healthy pregnant women. In anaemic women significant (p < 0.001) linear correlation between haemoglobin (hgb) and log serum EPO concentrations was observed. In pregnant women including both healthy and anaemic women log serum EPO concentrations correlated inversely with hgb concentrations (p < 0.01). We conclude that erythropoietin secretion is raised in normal pregnancy and is at highest in the first and second trimesters, when hgb mass begins to grow. In pregnancy with concomitant anaemia a more extensive demand for erythropoietin secretion is obvious.
我们发现，在正常妊娠期间血清促红细胞生成素（EPO）浓度显著升高（p < 0.01）。促红细胞生成素浓度在妊娠第24周之前显著高于（p < 0.05）该孕周之后。缺铁性贫血孕妇的血清EPO浓度显著高于（p < 0.001）健康孕妇。在贫血女性中，观察到血红蛋白（hgb）与血清EPO浓度对数之间存在显著的（p < 0.001）线性相关性。在包括健康和贫血女性的孕妇中，血清EPO浓度对数与hgb浓度呈负相关（p < 0.01）。我们得出结论，在正常妊娠中促红细胞生成素分泌增加，在hgb量开始增长的孕早期和孕中期最高。在伴有贫血的妊娠中，对促红细胞生成素分泌的需求明显更大。
