Bösch M F, Ludin H P
Klinik für Neurologie, Kantonsspitals St. Gallen.
Schweiz Arch Neurol Psychiatr (1985). 1994;145(5):8-13.
28 patients suffering from idiopathic Parkinson's disease received subcutaneous apomorphine for the treatment of painful dystonia and of off-phases of long duration. After a mean period of 12.4 months 20 patients still used apomorphine. In this time the mean dose per injection had fallen from 2.5 mg to 2.1 mg and the mean number of daily applications from 2.6 to 2.2. Most patients considered dystonias and off-phases to respond satisfactorily to apomorphine. However, in most cases the treatment effect was impaired by side effects, especially nausea.
28例特发性帕金森病患者接受皮下注射阿扑吗啡治疗疼痛性肌张力障碍和长期的“关”期。平均12.4个月后,20例患者仍在使用阿扑吗啡。在此期间,每次注射的平均剂量从2.5毫克降至2.1毫克,每日平均使用次数从2.6次降至2.2次。大多数患者认为肌张力障碍和“关”期对阿扑吗啡的反应令人满意。然而,在大多数情况下,治疗效果受到副作用的影响,尤其是恶心。